Category Biology/ Biotechnology

Scientists find Microbes on the Skin of Mice promote tissue Healing, Immunity

Highlights • Non-classical MHC class I molecules promote homeostatic immunity to the microbiota • Commensal-specific T cells express immunoregulatory and tissue repair signatures • Commensal-specific T cells accelerate wound closure

Highlights • Non-classical MHC class I molecules promote homeostatic immunity to the microbiota • Commensal-specific T cells express immunoregulatory and tissue repair signatures • Commensal-specific T cells accelerate wound closure

Insights may inform wound management techniques. Beneficial bacteria on the skin of lab mice work with the animals’ immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Researchers say untangling similar mechanisms in humans may improve approaches to managing skin wounds and treating other damaged tissues.

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Secrets of Longevity Protein revealed in New Study

Klotho proteins. Credit: Image courtesy of Yale University

Klotho proteins. Credit: Image courtesy of Yale University

Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the 3D structure of one of these proteins, beta-Klotho, illuminating its intricate mechanism and therapeutic potential. The study findings, published in Nature, could have implications for therapies developed to treat a wide range of medical conditions, including diabetes, obesity, and certain cancers, the researchers said.

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Key driver of Atopic Dermatitis discovered

Periostin (shown in pink) is being used in the clinic as a marker for allergic diseases such as asthma as well as atopic dermatitis. Left image: Periostin is overexpressed in atopic dermatitis. Right image: Blocking LIGHT also blocks periostin expression.

Periostin (shown in pink) is being used in the clinic as a marker for allergic diseases such as asthma as well as atopic dermatitis. Left image: Periostin is overexpressed in atopic dermatitis. Right image: Blocking LIGHT also blocks periostin expression.

Finding provides a novel therapeutic target for the treatment of severe eczema, a chronic inflammatory skin condition that is driven by an allergic reaction. In their latest study, researchers at La Jolla Institute reveal an important player that promotes skin inflammation in atopic dermatitis and the characteristic thickening of the skin...

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An eNose is able to Sniff out Bacteria that cause Soft Tissue Infections

Image result for An eNose is able to sniff out bacteria that cause soft tissue infections

Electronic Nose in the Detection of Wound Infection Bacteria from Bacterial Cultures: A Proof-of-Principle Study

A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections. The eNose can be used to detect the bacteria without the prior preparation of samples, and the system was capable of differentiating methicillin-resistant Staphylococcus aureus (MRSA) from methicillin-sensitive Staphylococcus aureus (MSSA).

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