Category Health/ Medical

Cannabis, ‘spice’ – better think twice

Natural (∆9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-10447-2

Natural (∆9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-10447-2

A research group of International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, discovered that seizures, a life-threatening condition, can be induced by natural Δ9-tetrahydrocannabinol (Δ9-THC, main constituent of marijuana) or the synthetic cannabinoid JWH-018 (main component of synthetic blend “Spice”) in mice. This was demonstrated by continuous recording of animals’ electric brain activity (electroencephalogram, EEG), video and movement activity tracking...

Read More

Locking down the Big Bang of Immune Cells

Schematic diagram showing how a subset of immune cells, named DN2a T cells, mature into DN2b T cells. The maturation of this step is among the earliest in immune cell development and is controlled by the forgotten DNA strands that allow the genome to change its architecture to induce the “Big Bang” of T cell development. In the absence of the “forgotten strands” DN2a cells fail to mature and ultimately after accumulating additional mutations become malignant T cells also named leukemias or lymphomas. Credit: UC San Diego

Schematic diagram showing how a subset of immune cells, named DN2a T cells, mature into DN2b T cells. The maturation of this step is among the earliest in immune cell development and is controlled by the forgotten DNA strands that allow the genome to change its architecture to induce the “Big Bang” of T cell development. In the absence of the “forgotten strands” DN2a cells fail to mature and ultimately after accumulating additional mutations become malignant T cells also named leukemias or lymphomas.
Credit: UC San Diego

Ignored pieces of DNA play a critical role in the development of immune cells (T cells). These areas activate a change in the structure of DNA that brings together crucial elements necessary for T cell formation...

Read More

Mechanism that underlies Age-Associated Bone Loss

osteoporosis ts

A protein called Cbf-beta plays a critical role in maintaining bone-producing cells. An examination of aged mice showed dramatically reduced levels of Cbf-beta in bone marrow cells, as compared to younger mice. Thus, the researchers propose, maintaining Cbf-beta may be essential to preventing human age-associated osteoporosis that is due to elevated creation of fat cells.

A major health problem in older people is age-associated osteoporosis that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow. University of Alabama at Birmingham researchers have now detailed an underlying mechanism leading to that osteoporosis. When this mechanism malfunctions, progenitor cells stop creating bone-producing cells, and instead create fat cells...

Read More

Being Active Saves Lives whether a Gym Workout, Walking to Work or Washing the Floor

Image result for walking to work o

Physical activity of any kind can prevent heart disease and death, says a large international study ...

Read More